A couple of consistent issues.

One problem I’ve run into is that none of the NPCs come with any weapons, armor or general gear which means that they are generally terrible when it comes to combat. This also becomes an issue with spell casters both not having any knowledge of spells and not utilizing them once I’ve set up a spell list by editing their characters.
Another issue I’ve noticed is the item editor not saving changes I’ve made, which can be problem when finess weapons won’t allow you to update them as such.